Liver Cancer: Symptoms, Signs, Causes & Treatment

Published in : Oncology | December 8, 2025 |

Liver Cancer: Symptoms, Signs, Causes & Treatment

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Liver cancer, also known as hepatocellular carcinoma (HCC), is one of the most common and life-threatening cancers worldwide. It develops primarily in the liver cells (hepatocytes) or the bile ducts (cholangiocarcinoma). With the increasing prevalence of fatty liver disease, hepatitis infections, and lifestyle-related conditions, liver cancer cases are rising globally, including in India. Early diagnosis and timely treatment are key to improving survival and quality of life.

Understanding Liver Cancer

The liver plays a vital role in metabolism, detoxification, and nutrient storage. When cancerous cells develop in the liver, they can disrupt these essential functions and spread rapidly.

Liver cancer can be primary, originating in the liver, or secondary (metastatic), where cancer spreads from other parts of the body, such as the colon, breast, or lungs.

Types of Liver Cancer

Hepatocellular Carcinoma (HCC):

The most common type of liver cancer, HCC, usually develops in people with chronic liver diseases such as cirrhosis or hepatitis B and C.

Bile Duct Cancer (Cholangiocarcinoma):

This cancer arises from the bile ducts inside or outside the liver. It is aggressive and often diagnosed at an advanced stage.

Angiosarcoma:

A rare form of liver cancer that originates in the blood vessels of the liver.

Hepatoblastoma:

A rare liver cancer found mainly in children, typically under the age of three.

Symptoms and Signs of Liver Cancer

In the early stages, liver cancer often causes no symptoms. As the disease progresses, signs may become more evident.

Common symptoms of liver cancer include:

  • Unexplained weight loss
  • Loss of appetite
  • Upper abdominal pain or swelling
  • Nausea and vomiting
  • General weakness or fatigue
  • Yellowing of the skin and eyes (jaundice)
  • Dark urine and pale stools
  • Itchy skin
  • Swelling in the legs (oedema)
  • Enlarged liver or spleen

If you experience any of these symptoms persistently, it is crucial to seek medical evaluation from an experienced oncologist in Bangalore for timely diagnosis.

Causes and Risk Factors

Liver cancer usually develops in individuals with underlying liver disease. Understanding the causes can help in prevention and early detection.

1. Chronic Viral Hepatitis

Long-term infection with Hepatitis B or Hepatitis C virus significantly increases the risk of developing hepatocellular carcinoma (HCC cancer).

2. Cirrhosis

Cirrhosis is a condition where healthy liver tissue is replaced by scar tissue, impairing liver function. It can result from chronic alcohol abuse, hepatitis, or non-alcoholic fatty liver disease.

3. Fatty Liver Disease

Non-alcoholic fatty liver (NAFLD) and non-alcoholic steatohepatitis (NASH) are increasingly recognised as major risk factors for liver cancer, especially in individuals with obesity, diabetes, or metabolic syndrome.

4. Alcohol Consumption

Chronic heavy alcohol intake can lead to liver inflammation, cirrhosis, and eventually liver cancer.

5. Aflatoxin Exposure

Aflatoxins are toxic substances produced by certain moulds found on improperly stored grains and nuts. Long-term exposure increases liver cancer risk.

6. Genetic Disorders

Conditions like hemochromatosis (iron overload) and Wilson’s disease (copper buildup) can also increase cancer risk.

7. Diabetes and Obesity

Both conditions contribute to fatty liver and insulin resistance, creating an environment conducive to cancer growth.

Diagnosis of Liver Cancer

Early detection is vital for effective treatment. At SPARSH Hospitals, our team employs cutting-edge diagnostic methods, including:

  • Blood Tests: To measure liver function and detect tumour markers such as alpha-fetoprotein (AFP).
  • Imaging Tests: Ultrasound, CT scan, MRI, and PET scan help visualise tumour size and spread.
  • Liver Biopsy: A small tissue sample is taken from the liver to confirm cancer type.
  • Endoscopy and Cholangiography: Used to assess bile duct cancer and related complications.

Stages of Liver Cancer

Liver cancer is classified into stages based on tumour size, spread, and liver function:

  • Stage I: Cancer is confined to the liver and has not spread.
  • Stage II: The tumour has grown into nearby blood vessels, or there are multiple small tumours.
  • Stage III: The cancer has spread to major blood vessels or nearby organs.
  • Stage IV Liver Cancer: Cancer has metastasised to distant parts of the body, such as the lungs or bones.

At SPARSH Hospitals, we offer personalised liver cancer treatment plans tailored to the stage and overall health of each patient.

Liver Cancer Treatment Options

Treatment for liver cancer depends on several factors, such as cancer stage, liver function, and patient health. The main options include:

1. Surgery

Partial Hepatectomy: Removal of the affected portion of the liver. Suitable for early-stage cancers with good liver function.

Liver Transplant for Stage 4 Liver Cancer:

In select cases, patients with advanced liver cancer may be eligible for a liver transplant, replacing the diseased liver with a healthy donor organ.

2. Radiation Therapy

Radiation therapy uses high-energy rays to target and destroy cancer cells. It is often used to shrink tumours before surgery or to relieve pain in advanced stages.

3. Chemotherapy

Chemotherapy may be administered intravenously or directly into the liver (hepatic artery infusion) to destroy cancer cells and prevent further spread.

4. Targeted Therapy

Drugs like sorafenib and lenvatinib are used to block specific pathways that promote cancer growth in HCC cancer.

5. Immunotherapy

This treatment boosts the body’s immune system to recognise and attack cancer cells. Drugs such as nivolumab and pembrolizumab have shown promising results.

6. Ablation Therapy

Techniques like radiofrequency ablation (RFA) and microwave ablation use heat to destroy cancerous tissue, especially in small tumours.

7. Palliative Care

For patients with stage 4 liver cancer, palliative care focuses on symptom management and improving quality of life.

Prevention of Liver Cancer

While not all cases are preventable, the risk can be significantly reduced through lifestyle and medical measures:

  • Get Vaccinated Against Hepatitis B
  • Avoid Excessive Alcohol Consumption
  • Maintain a Healthy Weight
  • Treat Hepatitis Infections Early
  • Eat a Balanced Diet rich in fruits, vegetables, and lean proteins
  • Avoid Aflatoxin-Contaminated Foods
  • Get Regular Health Checkups to monitor liver health

Why Choose SPARSH Hospitals for Liver Cancer Treatment

SPARSH Hospitals is recognised as one of the best cancer hospitals in Bangalore, offering comprehensive cancer care with advanced diagnostic tools and treatment technologies.

Our team includes the best oncologists in Bangalore, specialising in liver and gastrointestinal cancers. From early detection to complex surgeries and radiation therapy, we ensure personalised and compassionate care at every step.

Conclusion

Liver cancer is a serious condition, but early detection and timely treatment can significantly improve outcomes. Understanding the symptoms, causes, and treatment options is crucial for effective management.

At SPARSH Hospitals, we combine medical expertise, advanced technology, and a patient-centred approach to deliver the best possible care. If you or a loved one experiences signs of liver disease or has been diagnosed with liver cancer, consult our expert oncologists today for a comprehensive treatment plan.

Frequently Asked Questions

1. What are the early signs of liver cancer?

Early signs include fatigue, unexplained weight loss, loss of appetite, and abdominal discomfort.

2. Can fatty liver lead to cancer?

Yes, fatty liver and non-alcoholic steatohepatitis (NASH) can progress to cirrhosis and increase the risk of hepatocellular carcinoma.

3. What is the treatment for stage 4 liver cancer?

Stage 4 liver cancer treatment includes targeted therapy, immunotherapy, and, in select cases, liver transplant or palliative radiation therapy to manage symptoms.

4. Is liver cancer curable?

If detected early, liver cancer can be treated effectively through surgery, transplant, or localised therapies. Advanced stages focus on extending survival and improving quality of life.

5. Who are the best oncologists in Bangalore for liver cancer?

SPARSH Hospitals has some of the best oncologists in Bangalore, specialising in advanced HCC cancer management, offering cutting-edge treatments and compassionate care.


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