Respiratory Failure: Causes, Symptoms, and Treatment

Published in : Pulmonology | May 13, 2025 |

Respiratory Failure: Causes, Symptoms, and Treatment

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Respiratory failure is a serious condition where the lungs can’t supply enough oxygen to the blood or remove carbon dioxide from the body. It can develop suddenly, which is acute, or gradually, which is also called chronic, and requires prompt medical attention. Lung failure can result from various underlying issues, including infections, chronic diseases, or injury. Recognising the signs and understanding the causes of respiratory failure can lead to timely treatment and better outcomes.

What is Respiratory Failure?

Respiratory failure happens when the lungs fail to perform their essential function, which is the exchange of air. In this condition, either oxygen levels fall too low (hypoxemic respiratory failure), carbon dioxide levels rise too high (hypercapnic respiratory failure), or both. It can affect anyone, but it is more common in people with lung diseases or weakened immune systems.

There are two main types:

  • Acute respiratory failure: It develops rapidly and can be life-threatening.
  • Chronic respiratory failure: It progresses slowly over time and may be managed with long-term care.

Respiratory Failure Causes

Several medical conditions and environmental factors can lead to respiratory failure. The most common causes include:

1. Pneumonia

Pneumonia is a serious lung infection that inflames the air sacs and fills them with fluid or pus. This blocks oxygen from reaching the bloodstream, making it harder to breathe. It’s especially dangerous for older adults and people with weakened immune systems, often leading to lung failure if not treated promptly.

2. Chronic Obstructive Pulmonary Disease (COPD)

COPD is a long-term disease that causes airflow blockage and breathing problems. It includes conditions like emphysema and chronic bronchitis. Over time, the lungs lose their ability to function properly, which can result in chronic respiratory failure.

3. Asthma

Asthma causes the airways to become inflamed and narrow, making breathing difficult. During a severe asthma attack, airflow may be severely restricted, leading to a sudden drop in oxygen levels and potentially causing acute respiratory failure if not managed quickly.

4. Respiratory Syncytial Virus (RSV)

RSV is a contagious virus that affects the respiratory tract. While mild in most people, it can cause serious lung infections in infants, elderly people, and those with existing lung issues. Severe RSV infections can lead to respiratory failure, especially when the lungs are compromised.

5. Pulmonary Embolism

This occurs when a blood clot blocks an artery in the lungs, cutting off blood flow. Without proper oxygen exchange, the lungs can’t function normally, which can rapidly lead to respiratory failure. It’s a medical emergency that requires immediate treatment.

6. Drug Overdose or Sedatives

Some drugs, especially opioids and sedatives, slow down the body’s breathing reflex. In high doses, they can cause breathing to stop altogether or severely impair lung function, leading to carbon dioxide buildup and acute respiratory failure.

7. Neuromuscular Disorders

Conditions like ALS (Amyotrophic Lateral Sclerosis), muscular dystrophy, or spinal cord injuries weaken the muscles involved in breathing. As these muscles lose strength, the body struggles to maintain normal breathing, eventually causing chronic respiratory insufficiency or failure.

Respiratory Failure Symptoms

Recognising respiratory failure symptoms early is critical. Symptoms may vary depending on the severity and cause, but often include:

  • Shortness of breath, especially during activity or while resting
  • Rapid or shallow breathing
  • Confusion or drowsiness due to low oxygen levels
  • Bluish tint to lips, fingers, or skin (cyanosis)
  • Irregular heart rate
  • Fatigue or weakness
  • Chest discomfort

In severe cases, respiratory arrest can occur, which requires emergency intervention.

Respiratory Failure Treatment

Treatment depends on the underlying cause, type of failure, and the patient’s overall condition. Common approaches include:

1. Oxygen Therapy

Supplemental oxygen helps restore normal oxygen levels, especially in hypoxemic respiratory failure.

2. Ventilation Support

Mechanical ventilation, either invasive (via a tube) or non-invasive (like CPAP or BiPAP), may be used to support or take over breathing.

3. Medications

Depending on the cause, medications may include:

  • Antibiotics for infections like pneumonia
  • Bronchodilators for asthma or COPD
  • Steroids to reduce inflammation
  • Antivirals for RSV or other viral infections

4. Treating Underlying Conditions

Managing chronic diseases like COPD, heart failure, or neuromuscular disorders is essential for long-term respiratory health.

5. Lifestyle Changes and Pulmonary Rehab

Quitting smoking, eating a balanced diet, staying active, and attending pulmonary rehabilitation can help manage chronic respiratory failure.

When to See a Pulmonologist?

If you or someone you know experiences frequent shortness of breath, chronic cough, or symptoms of lung failure, consult a specialist. Early diagnosis and treatment can prevent serious complications. For those in Bangalore, seeking help from a pulmonologist in Bangalore at a reputed facility can ensure expert care.

Conclusion

Respiratory failure is a serious condition that requires immediate medical attention. Understanding the causes, spotting the symptoms, and getting timely treatment are key to recovery. Whether it’s due to pneumonia, RSV, or chronic lung diseases, the right care can significantly improve outcomes. If you’re at risk or showing symptoms, don’t wait—consult a pulmonologist at the best pulmonology hospital in Bangalore and take the first step toward better lung health.

Frequently Asked Questions

What causes respiratory failure?

Common respiratory failure causes include pneumonia, COPD, asthma, RSV, and pulmonary embolism. Drug overdose and neuromuscular diseases can also contribute.

What are the main symptoms of respiratory failure?

Respiratory failure symptoms include shortness of breath, confusion, fatigue, and bluish skin. In severe cases, breathing may stop entirely.

How is respiratory failure treated?

Respiratory failure treatment may involve oxygen therapy, ventilatory support, medications, and addressing the root cause of lung failure.

Is respiratory failure reversible?

It can be, especially if diagnosed early and the underlying cause is treatable. Chronic forms may need long-term management.

Can RSV cause respiratory failure?

Yes, Respiratory Syncytial Virus can lead to severe lung infections and cause respiratory failure, especially in infants and older adults.


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